Trial | NCT00530400  Report issue

Title

Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery
Prospective, Double-Blind, Randomized, Placebo-Controlled Trial of Single-Dose Cefuroxime Prophylaxis in Herniated Disk Surgery

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    cefuroxime ...

  • Study Participants

    1369
The purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk
Study Started
Apr 30
1994
Study Completion
Mar 31
2000
Last Update
Sep 17
2007
Estimate

Drug cefuroxime

preoperative intravenous 1.5g cefuroxime

Drug placebo

preoperative intravenous placebo

1 Experimental

intravenous 1.5g cefuroxime

2 Placebo Comparator

intravenous placebo

Criteria 

Inclusion Criteria:

Age older than 18
spinal surgery for herniated disk

Exclusion Criteria:

known or suspected hypersensitivity to cephalosporins
type I hypersensitivity to betalactamic antibiotics
severe renal function impairment
acquired immune deficiency syndrome (AIDS) or other conditions of severe immuno-suppression
antibiotic therapy for concomitant infection at the time of surgery
pregnancy
refusal to participate
No Results Posted