Trial | NCT00525967  Report issue

Title

Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    50
The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.
Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.
Study Started
Feb 28
2006
Study Completion
Oct 31
2007
Anticipated
Last Update
Sep 06
2007
Estimate

Drug Methadone plus Acetaminophen or Placebo

Methadone bid according to a established conversion morphine-to-methadone ratio plus Placebo or Acetaminophen qid

1 Active Comparator

Methadone plus Placebo

2 Experimental

Methadone plus Acetaminophen

Criteria 

Inclusion Criteria:

Clinical diagnosis of cancer pain
Regular use of oral Morphine

Exclusion Criteria:

Use of Acetaminophen in the last 48 hours
Renal or Hepatic failure
No Results Posted