Trial | NCT00520585  Report issue

Official Title

Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    None
The aim of this study is to evaluate influence of atorvastin on the repolarisation phase of cardiomyocytes. If there is any, it could be a part of positive "non-lipid" effect of statins in therapy of ischaemic heart disease.

Study hypothesis: atorvastin will decrease heterogeneity of repolarisation of cardiomyocytes in comparison with placebo
The group will consist of 40 healthy volunteers. The study will be mono-centric. The repolarisation phase of cardiomyocytes will be evaluated using long - term 12-lead digital ECG monitoring. There will be 3 single ECG recordings - randomly after 20 mg of atorvastin, 80 mg of atorvastatin and placebo, respectively.
Study Started
Aug 31
2007
Study Completion
Nov 30
2007
Anticipated
Last Update
Aug 24
2007
Estimate

Drug atorvastatin

atorvastatin 20 mg once vs. atorvastatin 80 mg once vs. placebo

Criteria 

Inclusion Criteria:

signed informed consent
age 18 - 45 years

Exclusion Criteria:

no chronic active disease
no concomitant pharmacotherapy, excluding hormonal contraception
abnormal ECG, echocardiography, laboratory findings
known hypersensitivity or myopathy due o statin
pregnancy, lactation, breast implants
skin disease
No Results Posted