Trial | NCT00507806  Report issue

Official Title

Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke

  • Phase

    Phase 1/Phase 2

  • Study Type

    Interventional

  • Status

    Terminated

  • Study Participants

    None
The study is designed to examine the safety, tolerability, and activity of a combination of microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.
Study Started
Mar 31
2005
Study Completion
May 31
2006
Last Update
Jul 27
2007
Estimate

Drug perflutren lipid microsphere

  • Other names: Definity

Criteria 

Inclusion Criteria:

Measurable focal neurological deficit (National Institutes of Health Stroke Scale [NIHSS] score > 4 points)
tPA eligible
Occlusion of the middle cerebral artery

Exclusion Criteria:

Right to left cardiac shunt
Uncontrolled hypertension
Absent temporal windows
No Results Posted