Title
Impact of Pitavastatin in Hypercholesterolemic Patients With Metabolic Syndrome
Multicenter Study for Anti-oxidative and Anti-inflammatory Effects of Pitavastatin in Hypercholesterolemic Patients With Metabolic Syndrome
Phase
Phase 4Lead Sponsor
Aichi Gakuin UniversityStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Metabolic Syndrome Oxidative Stress InflammationIntervention/Treatment
pitavastatin ...Study Participants
100The purpose of this study is to evaluate anti-oxidative and anti-inflammatory effects of pitavastatin in hypercholesterolemic patients with the metabolic syndrome.
The metabolic syndrome is defined as a cluster of cardiovascular risk factors including visceral obesity, dyslipidemia, elevated blood pressure and impaired glucose tolerance. Recently, it has been described that oxidative stress and inflammatory reaction, which are important in progression of atherosclerosis, increases in individuals with the metabolic syndrome. Statins might have beneficial effects such as anti-oxidative and anti-inflammatory actions that are independent from their cholesterol-lowering effects. Pitavastatin, a chemically synthesized statin, has potent LDL-cholesterol lowering and also anti-oxidative and anti-inflammatory effects in animal studies. However, the effects of pitavastatin on oxidative stress and inflammatory action in patients with the metabolic syndrome have not been reported.
Pitavastatin (2mg/day) was administered for 12 weeks
Inclusion Criteria: Hypercholesterolemic patients Exclusion Criteria: Patients receiving lipid-lowering agents Familial hypercholesterolemia Renal disease Diseases of liver, gallbladder and bile ducts Pregnant women