Trial | NCT00428428  Report issue

Official Title

Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract

  • Phase

    Phase 2/Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.
Study Started
Feb 28
2007
Study Completion
Nov 30
2007
Last Update
Nov 16
2007
Estimate

Drug Isoproterenol

ISO 0.1 microgram/ml, 8 ml/min irrigation compared to saline irrigation

1 Placebo Comparator

Saline irrigation

2 Active Comparator

ISO irrigation

Criteria 

Inclusion Criteria:

Indication for ureterorenoscopy
Age> 18 years
Normal blood pressure

Exclusion Criteria:

Malignant disease in the upper urinary tract
Heart disease
Allergy to Isoproterenol
Use of α-blocking or β-blocking medicine
Use of Calcium-antagonists
Use of NSAIDs the last 48 hours
Present stone or JJ-stent in the ureter
Neurologic disease in the bladder
Pregnancy
Nursing mothers
No Results Posted