Trial | NCT00426998  Report issue

Title

Combination Bevacizumab and Verteporfin (Two Different Sequences of Treatment)in Neovascular AMD
A 24 Month Randomized, Double-Masked, Single Center, Phase II Study Comparing Photodynamic Therapy With Verteporfin (Visudyne)Plus Two Different Timing Regimens of Intravitreal Bevacizumab (Avastin) Given 1 Week Prior to or 1 Week Following Photodynamic Therapy in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration.

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    30
The purpose of this research study is to compare different timing therapies of Verteporfin with Bevacizumab to treat choroidal neovascularization (CNV) due to age-related macular degeneration (AMD).
Study Started
Apr 30
2006
Last Update
Jan 26
2007
Estimate

Drug Verteporfin

Drug Bevacizumab

Criteria 

Inclusion Criteria:

Patients are men or women of age 55 or older
Patients have subfoveal CNV due to AMD with lesion size less than or equal to 9 MPS DA
patients have not received previous treatment for subfoveal CNV due to AMD.
Patients have a visual acuity between 20/40 and 20/320-

Exclusion Criteria:

Subjects who have received previous treatment for subfoveal CNV, in their study eye including prior PDT, transpupillary thermotherapy (TTT), submacular surgery, drug therapies such as Macugen or other anti-angiogenic compounds, or other local treatment. Previous laser photocoagulation therapy is acceptable, provided it was not subfoveal.
Patients with a known hypersensitivity/allergy to verteporfin, porfimer sodium, or other porphyrins, porphyria or other porphyrin sensitivity, or hypersensitivity to sunlight or bright artificial light.
Patients who use medications that may induce photosensitivity.
Patients who have undergone YAG capsulotomy within the last month.
Subjects currently involved in any experimental procedure within the last 12 weeks.

Female patients who are pregnant, fecund or breast-feeding.

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No Results Posted