Official Title
Adjunctive Glycine for Obsessive Compulsive Disorder
Phase
N/ALead Sponsor
New York UniversityStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Obsessive Compulsive DisorderIntervention/Treatment
glycine ...Study Participants
24The purpose of this study is to determine whether individuals with obsessive compulsive disorder who will take a preparation of the amino acid glycine in addition to their current treatment, may experience improvement in their symptoms.
Individuals with obsessive compulsive disorder (OCD) often find inadequate relief, even with the best of currently available treatments. Some evidence suggests the the neurotransmitter glutamate may be a useful target for new treatments for OCD. The amino acid glycine, if given orally in adequate dosages, can have specific effects on one particular glutamate receptor molecule in the brain, that might be helpful with OC symptoms. This randomized, double-blind protocol will have study participants who suffer with OCD take either a glycine preparation or placebo for 12 weeks. Clinical measures (e.g., Y-BOCS, NIMH-OC) will be recorded at each visit to determine whether those taking the glycine experience clinical benefit.
Inclusion Criteria: Diagnosis of OCD present for at least 1 year Male or female, age 18 to 65 Stable medication regimen for 12 weeks prior to study entry at least moderately severe OC symptoms Exclusion Criteria: Active substance use disorder within the last 6 months Comorbid schizophrenia, schizoaffective disorder, bipolar disorder, tic disorder, Tourette Disorder, schizotypal personality disorder Hoarding as the principal OCD symptom Insulin-dependent diabetes mellitus Pregnant or breastfeeding
