Trial | NCT00356226  Report issue

Title

The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    clonidine ...

  • Study Participants

    64
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.
Study Started
Oct 31
2000
Last Update
Dec 04
2006
Estimate

Drug clonidine

Criteria 

Inclusion Criteria:

Cirrhotic patients with ascites
Plasma norepinephrine level > 300 pg/mL (normal value: 185 - 275 pg/mL)

Exclusion Criteria:

Serum bilirubin concentration above 4.5 mg/dL
Prothrombin time below 40%
Platelet count below 40 X 10¨9/liter
Serum creatinine concentration above 2 mg/dL
Gastro-intestinal hemorrhage
Alcoholic hepatitis
Diabetes mellitus,
Hepatocellular carcinoma
Respiratory or cardiac failures
Hepatic encephalopathy
Bacterial infection
No Results Posted