Title
Intravenous Lidocaine and Acute Rehabilitation
Intravenous Lidocaine Infusion Improves Outcome After Laparoscopic Colectomy
Phase
Phase 4Lead Sponsor
University of RochesterStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Pain, Postoperative Opioid Consumption, Postoperative Postoperative FatigueIntervention/Treatment
lidocaine ...Study Participants
45Background: Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function. The investigators therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization.
Methods: Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg.kg-1 lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg-1.h-1 intraoperatively and 1.33 mg.kg-1.h-1 for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leucocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (median [25%-75% interquartile range] Saline vs Lidocaine groups) were analyzed using Mann-Whitney tests. P<0.05 was considered statistically significant.
Inclusion Criteria: ASA I-III non-malignant disease Exclusion Criteria: greater than 70 years history of gastro-duodenal peptic ulcer or renal failure (contraindications to the use of nonsteroidal anti-inflammatory drug) hepatic insufficiency psychiatric disorder steroid treatment chronic treatment with opioid