Trial | NCT00329485  Report issue

Title

The Effect of Ribose on B-Type Natriuretic Peptide (BNP) Levels in Congestive Heart Failure Patients
The Effect of Ribose on B-Type Natriuretic Peptide Levels in Congestive Heart Failure Patients

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Intervention/Treatment

    d-ribose ...

  • Study Participants

    120
The purpose of this research study is to test the effectiveness of CORvalen, a medical food, to increase cellular energy sufficiently to change or modify BNP levels in congestive heart failure patients.
B-type natriuretic peptide (BNP), is a blood test commonly used to track the progress of congestive heart failure. CORvalen, a medical food, contains D-Ribose (ribose), a natural substance that has been shown to improve the amount of energy compounds at the cellular level. Congestive heart failure has been associated with a reduced level of high-energy compounds. One researcher has called them an "energy starvation" in congestive heart failure. This study will try to assess if increasing the amount of these energy compounds is sufficient to improve BNP levels. Approximately 120 symptomatic congestive heart failure patients will participate in this 3 month study.
Study Started
Jun 30
2006
Study Completion
Jul 31
2007
Last Update
Aug 02
2007
Estimate

Drug CORvalen (D-Ribose)

Criteria 

Inclusion Criteria:

Symptomatic adults, M/F, between 18 and 80 years of age
BNP levels equal to or greater than 300 pg/ml.
Primary or secondary diagnosis of congestive heart failure at the time of admission (any NYHA Class)
Diagnosis of congestive heart failure for at least 3 months
Able to perform 6 minute hall walk
No therapeutic pharmaceutical class changes for at least 1 month
Provide informed consent
A 30-day washout period must be achieved for any patient involved in a previous clinical study.

Exclusion

Insulin dependent diabetes (Type I)
History of obstructive valvular disease
History of pulmonary hypertension within the last 3 months
History of hypertrophic or alcoholic cardiomyopathy
History of restrictive cardiomyopathy
History of reversible cardiomyopathy
History of non-compliance
Pregnancy
Current enrollment in any other clinical study
No Results Posted