Trial | NCT00213226  Report issue

Title

Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis
Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    urea ...

  • Study Participants

    120
This study is to determine the effectiveness of five-day treatment versus a single dose of oral dexamethasone (corticosteroid) in children between 2 and 24 months of age with a first episode of acute bronchiolitis presenting in the Emergency Department
Study Started
Dec 31
2001
Primary Completion
Apr 30
2006
Study Completion
Apr 30
2006
Last Update
May 13
2014
Estimate

Drug dexamethasone

Criteria 

Inclusion Criteria:

infants 2 to 24 months of age
acute bronchiolitis, defined as first episode of wheezing with upper respiratory infection and respiratory distress
moderate to severe baseline disease severity (Respiratory Distress Index (RDAI) score 6 to 15)
only patients discharged at or shortly after 240 minutes of uniform stabilization therapy will be randomized

Exclusion Criteria:

previous wheezing and/or bronchodilator therapy
hospitalization at 240 minutes
critically ill patients needing airway stabilization
patients with low or very high baseline disease severity (RDAI <5 and >16)
patients under 8 weeks of age
patients on corticosteroids prior to arrival at Emergency Department
contact with varicella within 21 days
past history of ventilation for greater than 24 hours
existing cardiopulmonary disease, multisystem disease or immunodeficiency
insufficient command of the English language
No Results Posted