Trial | NCT00199069  Report issue

Title

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)
Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93)

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    720
The study evaluates the efficacy and tolerability of a risk- and subtype-adapted chemotherapy over one year, followed by randomized either intensified or conventional maintenance therapy. It includes a distinct protocol for the subgroup 'mature B-ALL',
Study Started
Apr 30
1993
Primary Completion
Jan 31
1999
Study Completion
May 31
2001
Last Update
Mar 17
2023

Drug Asparaginase

Drug Vincristine

Drug Daunorubicin, Adriamycin

Drug Cyclophosphamide

Drug Ifosfamide

Drug Cytarabine

Drug Mitoxantrone

Drug Methotrexate

Drug 6-Mercaptopurine

Drug 6-Thioguanine

Drug VM26

Drug Dexamethasone / Prednisolone

Procedure CNS Irradiation

Procedure Mediastinal Irradiation

Procedure Stem Cell Transplantation

Criteria 

Inclusion Criteria:

Acute Lymphocytic Leukemia
Age 15 - 65 years

Exclusion Criteria:

Serious secondary diseases which may compromise intensified chemotherapeutical treatment
Serious psychiatric diseases, which may compromise compliance with therapy
HIV-1 or HIV-2 Infection
Pretreatment > 2 weeks or chemotherapy other than Vincristine and Steroids
Patients without central diagnosis who cannot be allocated to a risk group
No Results Posted