Title
Prevention of Contrast-Induced Nephropathy
Prevention of Contrast-Induced Nephropathy: a Randomized Controlled Trial of Saline + Furosemide + Mannitol in High Risk Patients Undergoing Cardiac Angiography
Phase
N/ALead Sponsor
University of AlbertaStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Contrast-induced Nephropathy Acute Renal Failure Chronic Renal FailureIntervention/Treatment
mannitol furosemide sodium chloride ...Study Participants
200Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.
The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.
We hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.
We define an episode of contrast nephropathy using the conventional often published definition of a 25% relative increase in serum creatinine OR a 44 umol absolute increase in serum creatinine within 48 hours of contrast exposure.
500 mls half-normal saline + 25g mannitol + 100 mg furosemide
500 mls half-normal saline
Saline hydration + mannitol + furosemide
Saline hydration without mannitol or furosemide
Inclusion Criteria: age > 21 years serum creatinine > 150 umol/L able and willing to provide informed consent Exclusion Criteria: known hypersensitivity to contrast, furosemide, or mannitol unable to tolerate a fluid load (e.g., acute pulmonary edema) ESRD, on dialysis previous enrollment in this study or previous contrast administration with the last 2 weeks refusal by treating physician
