Trial | NCT00159081  Report issue

Title

One Year Drug Treatment in First-Episode Schizophrenia
One Year Maintenance Treatment With Low Dose Haloperidol vs. Risperidone in First-Episode Schizophrenia

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    haloperidol ...

  • Study Participants

    159
Prospective, randomized, double-blind, multi-center study on 1 year course and treatment outcome under low-dose typical (haloperidol) vs. atypical neuroleptics (risperidone) in first-episode schizophrenia.
The objective of this multi-center study is to optimize the long-term treatment of patients with first episode schizophrenia. This investigation should contribute to the issue of effective relapse prevention in first-episode patients. 1-year maintenance neuroleptic treatment is done with low dose haloperidol or risperidone (target dose 2-4 mg/die).
Study Started
Nov 30
2000
Primary Completion
Jun 30
2005
Study Completion
Jun 30
2005
Last Update
Feb 07
2008
Estimate

Drug Haloperidol, Risperidone (drug)

targeted dose of 2-4 mg/day over 1 year

1 Experimental

Maintenance antipsychotic treatment with risperidone

2 Active Comparator

Maintenance antipsychotic treatment with haloperidol in low-dose

Criteria 

Inclusion Criteria:

After the acute treatment of the first-episode in schizophrenia (according ICD-10 F20)
Age between 18 and 55
Informed consent

Exclusion Criteria:

Residence outside of the catchment area
Legal reasons
Insufficient knowledge of the German language
Substance abuse or addiction
Pregnancy
Serious physical illness
Organic brain disease
Contraindication to neuroleptic treatment
No Results Posted