Trial | NCT00121524  Report issue

Title

Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Effects of Epinephrine and I.V. Needle on CPR Outcome

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    904
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.
In a randomized, controlled study of all out-of-hospital cardiac arrest patients in Oslo, Norway, half the patients are treated according to the international guidelines for advanced CPR, and the other half according to the same guidelines, except for no I.V. needle or drugs are given until 5 minutes after eventual return of spontaneous circulation.
Study Started
Jan 31
2003
Primary Completion
May 31
2008
Study Completion
Jun 30
2008
Last Update
May 29
2015
Estimate

Drug Epinephrine

Epinephrine 1 mg is given iv. every 3 min during CPR

  • Other names: Adrenaline

Device Intravenous needle

An intravenous needle in placed as soon as possible during CPR

Drug Atropine

Atropine 3 mg iv in initial systole

  • Other names: Atropine sulfate

Drug Amiodarone

amiodarone 300 mg iv after repeated failed defibrillation attempts

  • Other names: Amiodaron

IV yes Experimental

Intravenous needle Epinephrine q 3 min during CPR Atropine 3 mg in initial asystole Amiodarone 300 mg iv after repeated failed defibrillation attempts

IV no No Intervention

The patient will not have an intravenous needle placed or given any drugs during CPR. If patient obtains spontaneous circulation, an intravenous needle is placed and patient can receive any drugs that are appropriate during the following treatment.

Criteria 

Inclusion Criteria:

Cardiac arrest out-of-hospital

Exclusion Criteria:

<18 years old
Trauma as cause of arrest
No Results Posted