Title
Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
Phase II Open-Label, Non-Randomized, Multicenter Study of Interstitial 131I-chTNT-1/B for the Treatment of Newly Diagnosed or Recurrent Malignant Glioma
Phase
Phase 2Lead Sponsor
Avid BioservicesStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Brain and Central Nervous System TumorsIntervention/Treatment
chtnt-1 ...Study Participants
60RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for some types of brain tumors.
PURPOSE: Phase II trial to study the effectiveness of radiolabeled monoclonal antibody in treating patients who have glioblastoma multiforme or anaplastic astrocytoma.
OBJECTIVES:
Determine the median time to disease progression in patients with newly diagnosed unresectable glioblastoma multiforme (GBM), recurrent GBM, or recurrent anaplastic astrocytoma treated with interstitial iodine I 131 monoclonal antibody TNT-1/B.
Determine the median survival time of these patients treated with this regimen.
Determine the safety of this regimen in terms of neurotoxicity, renal, hepatic, hematologic, and biochemical profiles in these patients.
Confirm the maximum tolerated dose of this regimen in these patients.
Optimize the drug delivery of this regimen in these patients.
Assess the response of these patients in terms of MRI measured gadolinium enhanced tumor volume and gadolinium enhanced tumor area at 8 and 12 weeks following the last dose of study drug.
OUTLINE: This is a multicenter study.
Patients undergo stereotactic implantation of 2 interstitial catheters into the tumor bed. One day later, patients receive iodine I 131 monoclonal antibody TNT-1/B interstitially over approximately 24 hours. At selected centers, up to 3 additional groups of 3 patients each will receive study drug up to 48 hours. Catheters are removed 1 day after completion of the infusion. A gadolinium enhanced MRI is performed during week 8. Patients with partial response, minimal response, or stable disease repeat the above treatments during week 9. Patients with complete response, progressive disease, or unacceptable toxicity receive no additional treatment.
Patients are followed every month until disease progression. All patients regardless of disease progression or retreatment are followed at 36 weeks.
PROJECTED ACCRUAL: A total of 60 patients (20 patients with newly diagnosed unresectable glioblastoma multiforme [GBM]; 20 patients with recurrent GBM; and 20 patients with recurrent anaplastic astrocytoma) will be accrued for this study.
DISEASE CHARACTERISTICS: Histologically confirmed newly diagnosed unresectable glioblastoma multiforme (GBM), recurrent GBM, or recurrent anaplastic astrocytoma (AA) MRI scan documenting gadolinium enhanced tumor volume of at least 5 cm3, but no greater than 60 cm^3 Recurrent GBM and AA must be documented by MRI after the most recent treatment and before any planned surgical debulking At least 5 days since prior surgical debulking No planned resection of newly diagnosed GBM before or during study No bilateral noncontiguous gadolinium enhancing tumors No satellite lesions greater than 1.5 cm from anticipated location of interstitial catheter tip No more than 2 satellite lesions PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: Not specified Hematopoietic: Platelet count at least 100,000/mm^3 Absolute neutrophil count at least 1,500/mm^3 WBC at least 3,000/mm^3 Hepatic: Hepatitis B surface antigen negative Bilirubin no greater than 2.5 times upper limit of normal (ULN) SGOT and SGPT no greater than 3 times ULN Alkaline phosphatase no greater than 3 times ULN Lactic dehydrogenase no greater than 3 times ULN Prothrombin time no greater than 1.5 times ULN Renal: Creatinine clearance at least 50 mL/min Cardiovascular: No significant unstable cardiovascular disease No New York Heart Association class III/IV heart disease No evidence of myocardial infarction within the past 3 months Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception Human antichimeric antibody (HACA) titer no greater than 48 ng/mL No anatomical or physiological considerations that would preclude study participation No active autoimmune disease, active infection, or traumatic injury requiring treatment HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior intravenous chemotherapy or Gliadel wafers Endocrine therapy: Not specified Radiotherapy: At least 8 weeks since prior external beam or gamma knife radiotherapy Surgery: See Disease Characteristics Other: At least 30 days since prior investigational treatment
