Related MeSH Hierarchy (4)
Anatomy [A] » Cells [A11] » Cellular Structures » Intracellular Space » Cytoplasm » Cytoplasmic Structures » Cytoskeleton » Actin Cytoskeleton » Filamins
Chemicals and Drugs [D] » Macromolecular Substances [D05] » Polymers » Biopolymers » Microfilament Proteins » Filamins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Contractile Proteins » Filamins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Cytoskeletal Proteins » Microfilament Proteins » Filamins
Description
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences. MeSH
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