Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Ligases » Ubiquitin-Protein Ligase Complexes » Ubiquitin-Protein Ligases » Anaphase-Promoting Complex-Cyclosome
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Cell Cycle Proteins » Anaphase-Promoting Complex-Cyclosome
Description
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. MeSH
Hierarchy View
Subtype Terms (12)
Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
Hierarchy Tree View
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