Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intercellular Signaling Peptides and Proteins » Cytokines » Transforming Growth Factor beta » Transforming Growth Factor beta1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intercellular Signaling Peptides and Proteins » TGF-beta Superfamily Proteins » Transforming Growth Factor beta » Transforming Growth Factor beta1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intercellular Signaling Peptides and Proteins » Cytokines » Transforming Growth Factor beta » Transforming Growth Factor beta1
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intercellular Signaling Peptides and Proteins » TGF-beta Superfamily Proteins » Transforming Growth Factor beta » Transforming Growth Factor beta1
Chemicals and Drugs [D] » Biological Factors [D23] » Intercellular Signaling Peptides and Proteins » Cytokines » Transforming Growth Factor beta » Transforming Growth Factor beta1
Chemicals and Drugs [D] » Biological Factors [D23] » Intercellular Signaling Peptides and Proteins » TGF-beta Superfamily Proteins » Transforming Growth Factor beta » Transforming Growth Factor beta1
Description
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME. MeSH
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