Chemicals and Drugs [D] » Lipids [D10] » Lipoproteins » Apolipoproteins » Apolipoproteins C » Apolipoprotein C-III
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Apoproteins » Apolipoproteins » Apolipoproteins C » Apolipoprotein C-III
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Lipoproteins » Apolipoproteins » Apolipoproteins C » Apolipoprotein C-III
Description
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2). MeSH
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