Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Serpins » Complement C1 Inactivator Proteins » Complement C1 Inhibitor Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Blood Proteins » Immunoproteins » Complement System Proteins » Complement Inactivator Proteins » Complement C1 Inactivator Proteins » Complement C1 Inhibitor Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » Complement C1 Inhibitor Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Serpins » Complement C1 Inactivator Proteins » Complement C1 Inhibitor Protein
Description
An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II. MeSH
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