Chemicals and Drugs [D] » Chemical Actions and Uses [D27] » Pharmacologic Actions » Molecular Mechanisms of Pharmacological Action » Neurotransmitter Agents » Histamine Agents » Histamine Antagonists » Histamine H1 Antagonists » Histamine H1 Antagonists, Non-Sedating
Chemicals and Drugs [D] » Chemical Actions and Uses [D27] » Pharmacologic Actions » Physiological Effects of Drugs » Neurotransmitter Agents » Histamine Agents » Histamine Antagonists » Histamine H1 Antagonists » Histamine H1 Antagonists, Non-Sedating
Description
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. MeSH
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Phase 1 Indicated Drugs (1)
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