Chemicals and Drugs [D] » Complex Mixtures [D20] » Venoms » Mollusk Venoms » Conotoxins
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Marine Toxins » Mollusk Venoms » Conotoxins
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Venoms » Mollusk Venoms » Conotoxins
Description
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) MeSH
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