Chemicals and Drugs [D] » Hormones, Hormone Substitutes, and Hormone Antagonists [D06] » Hormone Antagonists » Estrogen Receptor Modulators » Selective Estrogen Receptor Modulators
Chemicals and Drugs [D] » Chemical Actions and Uses [D27] » Pharmacologic Actions » Physiological Effects of Drugs » Hormones, Hormone Substitutes, and Hormone Antagonists » Hormone Antagonists » Estrogen Receptor Modulators » Selective Estrogen Receptor Modulators
Description
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) MeSH
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