Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Structures » Genome » Genome Components » Genes » Genes, Neoplasm » Oncogenes » Proto-Oncogenes » Genes, myb
Description
Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995). MeSH
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