Related MeSH Hierarchy (4)
Diseases [C] » Neoplasms [C04] » Paraneoplastic Syndromes » Paraneoplastic Syndromes, Nervous System » Paraneoplastic Cerebellar Degeneration
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Cerebellar Diseases » Paraneoplastic Cerebellar Degeneration
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Paraneoplastic Syndromes, Nervous System » Paraneoplastic Cerebellar Degeneration
Diseases [C] » Neoplasms [C04] » Neoplasms by Site » Nervous System Neoplasms » Paraneoplastic Syndromes, Nervous System » Paraneoplastic Cerebellar Degeneration
Description
Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686) MeSH
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