Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E] » Investigative Techniques [E05] » Genetic Techniques » Genetic Engineering » Protein Engineering » Amino Acid Substitution
Phenomena and Processes [G] » Genetic Phenomena [G05] » Mutagenesis » Amino Acid Substitution
Description
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties. MeSH
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