Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Organic Chemicals [D02] » Carboxylic Acids » Acids, Acyclic » Sugar Acids » Glyceric Acids » Diphosphoglyceric Acids » 2,3-Diphosphoglycerate
Chemicals and Drugs [D] » Organic Chemicals [D02] » Carboxylic Acids » Hydroxy Acids » Sugar Acids » Glyceric Acids » Diphosphoglyceric Acids » 2,3-Diphosphoglycerate
Chemicals and Drugs [D] » Organic Chemicals [D02] » Organophosphorus Compounds » Organophosphates » Diphosphoglyceric Acids » 2,3-Diphosphoglycerate
Chemicals and Drugs [D] » Carbohydrates [D09] » Sugar Acids » Glyceric Acids » Diphosphoglyceric Acids » 2,3-Diphosphoglycerate
Description
A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508) MeSH
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