Related MeSH Hierarchy (7)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intercellular Signaling Peptides and Proteins » Kinins » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Blood Proteins » Blood Coagulation Factors » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intercellular Signaling Peptides and Proteins » Kinins » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Protein Precursors » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Biological Factors [D23] » Blood Coagulation Factors » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Biological Factors [D23] » Inflammation Mediators » Autacoids » Kinins » Kininogens » Kininogen, High-Molecular-Weight
Chemicals and Drugs [D] » Biological Factors [D23] » Intercellular Signaling Peptides and Proteins » Kinins » Kininogens » Kininogen, High-Molecular-Weight
Description
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed) MeSH
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