Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Variation » Mutation » Allelic Imbalance » Loss of Heterozygosity
Description
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. MeSH
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Subtype Terms (2)
Chromosome Deletion
1 experimental drug
Haploinsufficiency
1 experimental drug
Phase 2 Indicated Drugs (1)
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