Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Disintegrins
Description
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. MeSH
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