Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Structures » Genome » Genome Components » Genes » Genes, Neoplasm » Oncogenes » Proto-Oncogenes » Genes, erbA
Description
Genes related to the erbA DNA sequence that was first isolated from the avian erythroblastosis virus (ERYTHROBLASTOSIS VIRUS, AVIAN), v-erbA. In cells, erbA genes encode thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA genes have been identified: erbA-alpha located at 17q21; and erbA-beta located at 3p24. Truncations at the N- and C-terminals of erbA result in products resembling v-erbA. Truncations affect hormone responsiveness but not DNA binding capacity. MeSH
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