Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Surface » Antigens, Differentiation » Antigens, Differentiation, T-Lymphocyte » CD3 Complex
Chemicals and Drugs [D] » Biological Factors [D23] » Biomarkers » Antigens, Differentiation » Antigens, Differentiation, T-Lymphocyte » CD3 Complex
Description
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). MeSH
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