Chemicals and Drugs [D] » Macromolecular Substances [D05] » Polymers » Biopolymers » Intermediate Filament Proteins » Neurofilament Proteins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Cytoskeletal Proteins » Intermediate Filament Proteins » Neurofilament Proteins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nerve Tissue Proteins » Neurofilament Proteins
Description
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) MeSH
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