Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, 1-Ring » Pyrans » Benzopyrans » Aflatoxins » Aflatoxin B1
Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, Fused-Ring » Heterocyclic Compounds, 2-Ring » Benzopyrans » Aflatoxins » Aflatoxin B1
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Mycotoxins » Aflatoxins » Aflatoxin B1
Description
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1. MeSH
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