Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E] » Investigative Techniques [E05] » Genetic Techniques » Genetic Engineering » Protein Engineering » Mutagenesis, Insertional
Phenomena and Processes [G] » Genetic Phenomena [G05] » Genetic Variation » Mutation » Mutagenesis, Insertional
Phenomena and Processes [G] » Genetic Phenomena [G05] » Mutagenesis » Mutagenesis, Insertional
Description
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation. MeSH
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