Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, 1-Ring » Pyrimidines » Pyrimidine Nucleosides » Cytidine » Deoxycytidine » Zalcitabine
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleosides » Deoxyribonucleosides » Deoxycytidine » Zalcitabine
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleosides » Deoxyribonucleosides » Dideoxynucleosides » Zalcitabine
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleosides » Pyrimidine Nucleosides » Cytidine » Deoxycytidine » Zalcitabine
Description
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. MeSH
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