Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Viral Proteins » Antigens, Viral » HIV Antigens » HIV Envelope Protein gp120
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Viral Proteins » Retroviridae Proteins » Gene Products, env » env Gene Products, Human Immunodeficiency Virus » HIV Envelope Protein gp120
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Viral Proteins » Retroviridae Proteins » Human Immunodeficiency Virus Proteins » env Gene Products, Human Immunodeficiency Virus » HIV Envelope Protein gp120
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Viral Proteins » Viral Structural Proteins » Viral Envelope Proteins » Gene Products, env » env Gene Products, Human Immunodeficiency Virus » HIV Envelope Protein gp120
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Viral » HIV Antigens » HIV Envelope Protein gp120
Description
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV. MeSH
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