Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Proteinase Inhibitory Proteins, Secretory » Serine Peptidase Inhibitors, Kazal Type » Trypsin Inhibitor, Kazal Pancreatic
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Blood Proteins » Acute-Phase Proteins » Trypsin Inhibitor, Kazal Pancreatic
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Proteinase Inhibitory Proteins, Secretory » Serine Peptidase Inhibitors, Kazal Type » Trypsin Inhibitor, Kazal Pancreatic
Description
A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS. MeSH
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