Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Bacterial Proteins » Tetanus Toxin
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Bacterial Toxins » Tetanus Toxin
Description
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS. MeSH
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