Chemicals and Drugs [D] » Macromolecular Substances [D05] » Multiprotein Complexes » Multienzyme Complexes » Pyruvate Dehydrogenase Complex
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Multienzyme Complexes » Pyruvate Dehydrogenase Complex
Description
A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) MeSH
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