Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E] » Investigative Techniques [E05] » Genetic Techniques » Nucleic Acid Denaturation
Phenomena and Processes [G] » Chemical Phenomena [G02] » Biochemical Phenomena » Nucleic Acid Denaturation
Phenomena and Processes [G] » Genetic Phenomena [G05] » Nucleic Acid Denaturation
Description
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible. MeSH
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