Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Inorganic Chemicals [D01] » Free Radicals » Nitric Oxide
Chemicals and Drugs [D] » Inorganic Chemicals [D01] » Nitrogen Compounds » Nitrogen Oxides » Nitric Oxide
Chemicals and Drugs [D] » Inorganic Chemicals [D01] » Nitrogen Compounds » Reactive Nitrogen Species » Nitric Oxide
Chemicals and Drugs [D] » Inorganic Chemicals [D01] » Oxygen Compounds » Oxides » Nitrogen Oxides » Nitric Oxide
Description
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. MeSH
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