Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Serpins » Antithrombin Proteins » Hirudins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Serpins » Antithrombin Proteins » Hirudins
Description
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN. MeSH
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