Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Carbon-Carbon Lyases » Carboxy-Lyases » Glutamate Decarboxylase
Description
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15. MeSH
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