Related MeSH Hierarchy (5)
Diseases [C] » Neoplasms [C04] » Neoplasms by Histologic Type » Neoplasms, Connective and Soft Tissue » Neoplasms, Connective Tissue » Neoplasms, Bone Tissue » Osteochondroma » Osteochondromatosis » Exostoses, Multiple Hereditary
Diseases [C] » Neoplasms [C04] » Neoplastic Syndromes, Hereditary » Exostoses, Multiple Hereditary
Diseases [C] » Musculoskeletal Diseases [C05] » Bone Diseases » Bone Diseases, Developmental » Osteochondrodysplasias » Osteochondroma » Osteochondromatosis » Exostoses, Multiple Hereditary
Diseases [C] » Musculoskeletal Diseases [C05] » Bone Diseases » Hyperostosis » Exostoses » Exostoses, Multiple Hereditary
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Neoplastic Syndromes, Hereditary » Exostoses, Multiple Hereditary
Description
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation. MeSH
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