Chemicals and Drugs [D] » Organic Chemicals [D02] » Carboxylic Acids » Acids, Acyclic » Carbamates » Thiocarbamates » Ditiocarb » Disulfiram
Chemicals and Drugs [D] » Organic Chemicals [D02] » Sulfur Compounds » Sulfides » Disulfides » Disulfiram
Chemicals and Drugs [D] » Organic Chemicals [D02] » Sulfur Compounds » Thiocarbamates » Ditiocarb » Disulfiram
Description
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. MeSH
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