Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Bacterial Toxins » Cholera Toxin
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Enterotoxins » Cholera Toxin
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Glycosyltransferases » Pentosyltransferases » ADP Ribose Transferases » Cholera Toxin
Description
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. MeSH
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