Phenomena and Processes [G] » Immune System Phenomena [G12] » T-Cell Exhaustion
Description
Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions. MeSH
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